Reaction
Pharmira offers best solution to the themes given by our
clients through studying possibility both batch and
flow technology including process safeness.
Example of flow reaction
Gas-liquid reaction
Example to show the improvement of reaction rate by adopting flow reaction
Batch
In the condition of same injection scale, reaction rate depends on size of reactor (volume of gas layer, area between gas and liquid boundary ). In addition, scale up risk exists in scaling up from flask scale to tank scale.
Flow
Improvement of gas-liquid contacting efficiency
Photoreaction
Success for 60 times speed-up from initial laboratory scale condition by considering & designing conditions such as illuminant, solvent, photocatalyst.
- ➡Facility design without ineffectiveness of light (by utilizing simulation technology)
・Uniformed flow in the reactor
・No remained gas bubble in the reactor produced by reaction
Commercialization is realized in Tokushima Plant of Shionogi Pharma.
Commercialization is realized in Tokushima Plant of Shionogi Pharma compliant with GMP
Road to scale up
Achieving scale-up by figuring out parameter of light illumination and utilizing simulation technology
