1. Pharmira Co., Ltd.
  2. Facilities

Facilities

Facilities

Pharmira’s solution by batch facility with considerable experience & track record and innovative continuous manufacturing facility.

Manufacturing Facility

We offer investigational new drugs and intermediates in building A with two multi-purpose manufacturing lines and building B with three manufacturing lines for APIs and intermediates.

API Manufacturing Building A

Building A is our manufacturing plant for investigational new APIs and intermediates. The plant has 2 multi-purpose manufacturing lines for API and intermediates and ISO class 7 clean room to enable trial manufacturing of a wide range of APIs.

API Manufacturing Building A

Manufacturing Area

Reactor with Distiller 200~500L GL・SS
Reactor 300~800L GL
-70˚C Low Temperature Reactor 300L GL
Medium Pressure Reactor 500L GL
Centrifuge 30 inch TL
Conical Dryer 400L GL

Clean Room (ISO Class7)

Reactor with Distiller 300L GL
Centrifuge 24inch TL
Dryer Blender 150L GL

API Manufacturing Building B

Building B is for manufacturing of investigational new APIs(Active Pharmaceutical Ingredient) and intermediates and with 3 manufacturing lines, it has a larger manufacturing capacity than Building A. The manufacturing equipment line-up includes PAT equipment such as FBRM (Focused Beam Reflectance Measurement) to enable real time process monitoring. The clean room is equipped with Jet Mill to handle clients’ requests for manufacturing of investigational new APIs.

API Manufacturing Building B

Manufacturing Area

Reactor with Distiller 200~1000L GL・SS
Filter 150~330L SS, TL
Centrifuge 24, 30 inch TL
Conical Dryer 300L 500L GL

Clean Room (ISO Class 7)

Reactor with Distiller 1000L GL
Centrifuge 30 inch TL
Conical Dryer 500L GL
Pulverizer Jet Mill SS

New Building (to be constructed in 2023)

We are constructing new building where continuous manufacturing facility will be operated so that we will be able to offer hybrid (continuous technology & batch technology) solution with adjacent API Manufacturing Building A & B. Facilities that realize continuous reaction and continuous crystallization are delivered to API Manufacturing Building A accordingly and we offer feasibility study to adopt continuous manufacturing technology.

Facilities

Manufacturing Area Flow reaction facility (Material:Metal-free and hastelloy), Agitation (20L GL)
Production Area Crystallizer, Wet grinding mill, Nutche filter, Filter dryer (10L GL), Shelf-type vacuum dryer
R&D Area Flow reaction facility (I, II and III phase reaction, photoreaction, electrolytic reaction), continuous crystallizer, micronizerShelf-type vacuum dryer
Others Off-line/On-line analysis equipment

Continuous Manufacturing Facilities

Facilities (10-20g/hour) for R&D phase are installed. Our data and experience are mounted though activities such as study for merit of flow reaction. We are going to install new manufacturing facilities (100-200g/hour) for investigational new API in 2022 to realize smooth transfer from R&D phase to IND phase.

Reaction Facility

HEL_Flowcat

HEL_Flowcat

Syrris Asia
 (flow reaction equipment, study purpose)

Syrris Asia
(flow reaction equipment, study purpose)

Vapourtech
 (flow reaction equipment, study purpose)

Vapourtec
(flow reaction equipment, study purpose)

Mettler Toledo Easy Max
 (batch reaction equipment, study purpose)

Mettler Toledo Easy Max
(batch reaction equipment, study purpose)

Crystallization Facility

Continuous Crystallization Facility

Continuous Crystallization Facility

 
 

Process Analytical Technology (PAT)

PAT tool

PAT tool

 
 

For document requests and inquiries,
please contact us using the email form below or by phone.

Inquiries by phone

+81-6-6401-1324

Business Hours:9:00-17:00 JST(excludes weekends)