Continuous crystallization

Our continuous crystallization controls crystal size, particle size and quality of APIs which have influence on the feature of formulation and pharmacokinetics, therefore, we offer efficient and reproducible crystallization without milling process.

Particle size control

Crystallization, as one of the most important unit operations to determine physical property of APIs

• ➡Crystal particle size of APIs has influence on elution of formulation.
  ・Milling process is usually necessary in traditional batch crystallization due to producing crystal with broadened particle size distribution
• ➡Impurities (By-product) is occasionally produced due to physical energy of milling.

Batch crystallization

Example of continuous crystallization

Continuous crystallization can realize selective collection of crystal during growing process

• ➡Desired particle size and uniformed crystal can be produced, therefore, omission of milling process is anticipated.
  (contribution for shortening manufacturing time, cost reduction for manufacturing)